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KMID : 0606919980060010073
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Biomolecules & Therapeutics
1998 Volume.6 No. 1 p.73 ~ p.81
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Peri- and Postnatal Study of Q-35, a Quinolone Antibiotic, in Rats
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Han Soon-Young
Kim Pan-Gyi
Shin Jae-Ho
Cho In-Koo
Jang Seung-Jae
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Abstract
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Pregnant Sprague-Dawley rats were administered with Q-35 at the dose levels of 0, 30, 100 and 300 mg/kg/day by oral gavage from gestation day 17 to lactation period. Effects of the test chemical on general findings, reproductive performance of dams and development of Fl generation were examined. There were no treatment related changes in physical signs, body weight, necropsy findings, organ weights, delivery and nursing behavior. In 100 and 300 mg/fg/day treated groups, the food consumption of dams was decreased significantly during gestational day 19~21. The gestation length of 300 mg/tg/day treated group was increased significantly compared to the control group (22.3 ± 0.48 vs 22.0 ± 0.39). Although the gestational length of all groups were in normal range of the rat, potential effect of the drug could not be ruled out. External anomaly of Fl fetus induced by Q-35 was not detected in any groups. There were no treaoent related changes in physical development, reflex functions, sensory functions, locomotor activity and motor coordinating activity. Estrus cycle, fertility and reproductive performance of Fl were not changed in all treated groups. There was no external abnormality related to the drug administration on the examination of F2. These results suggest that Q-35 has no adverse effect on the peri- and postnatal period in rats except the reduction of food consumption at the beginning of drug administration and the potential effect on the elongation of gestation length.
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KEYWORD
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Q-35, quinolone, peri- and postnatal study, rats, physical development, behavior
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